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Working memory in the aged Ts65Dn mouse, a model for Down syndrome.

Katharine N Whitney1, Galen R Wenger

  • 1University of Arkansas for Medical Sciences, Slot 638, 4301 W. Markham, Little Rock, AR 72205, USA. kwhitney@uams.edu

Behavioural Brain Research
|April 17, 2012
PubMed
Summary

Aged Ts65Dn mice, a model for Down syndrome, do not show working memory deficits. Lifespan studies confirm these mice maintain cognitive function comparable to controls as they age.

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Area of Science:

  • Neuroscience
  • Genetics
  • Animal Models

Background:

  • The Ts65Dn mouse model exhibits traits similar to Down syndrome.
  • Down syndrome is linked to an increased risk of early-onset Alzheimer's disease.
  • Working memory deficits are a hallmark of Alzheimer's disease.

Purpose of the Study:

  • To investigate working memory in aged Ts65Dn mice.
  • To compare the cognitive performance of aged Ts65Dn mice with age-matched controls.
  • To further characterize the Ts65Dn mouse as a model for Down syndrome phenotypes.

Main Methods:

  • Utilized a titrating, delayed matching-to-position schedule of reinforcement.
  • Trained two groups of mice: one starting at 3 months, another at 15 months of age.
  • Monitored performance until 24 months of age for both groups.

Main Results:

  • Initially, both Ts65Dn groups showed lower accuracy than controls.
  • Accuracy differences between Ts65Dn and control mice diminished with continued training.
  • Aged Ts65Dn mice did not exhibit a working memory deficit compared to controls.

Conclusions:

  • Aged Ts65Dn mice do not display a working memory deficit.
  • The Ts65Dn mouse model may not fully replicate age-related cognitive decline seen in Alzheimer's disease.
  • Further research is needed to fully understand the cognitive phenotype of the Ts65Dn mouse over its lifespan.