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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

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Bernard E Van Beers¹, Catherine M Pastor, Hero K Hussain

¹Laboratoire d'Imagerie Physiologique et Moléculaire de l'Abdomen et Service de Radiologie, Université Paris Diderot, Sorbonne Paris Cité, INSERM UMR 773, Hôpitaux Universitaires Paris Nord Val de Seine, Beaujon, Clichy, France. bernard.van-beers@bjn.aphp.fr

Journal of Hepatology

|April 17, 2012

Summary

Gadolinium ethoxybenzyl dimeglumine (Gd-EOB-DTPA) is a liver-specific MRI contrast agent. It enhances liver lesion detection and characterization by providing both dynamic and hepatobiliary phase information.

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Area of Science:

Radiology
Hepatology
Medical Imaging

Background:

Liver-specific contrast agents improve diagnostic accuracy in liver imaging.
Gadolinium ethoxybenzyl dimeglumine (Gd-EOB-DTPA) offers unique hepatobiliary excretion properties.

Purpose of the Study:

To evaluate the diagnostic utility of Gd-EOB-DTPA in liver imaging.
To highlight the advantages of Gd-EOB-DTPA over non-specific contrast agents.

Main Methods:

Intravenous administration of Gd-EOB-DTPA.
Assessment of contrast distribution during dynamic and hepatobiliary phases.
Evaluation of hepatocyte uptake via OATP1B1/B3 and biliary excretion via MRP2.

Main Results:

Gd-EOB-DTPA shows similar distribution to non-specific agents in dynamic phases.
Significant hepatobiliary phase enhancement improves detection/characterization of focal and diffuse liver diseases.
Enhanced detection of metastases, cirrhotic nodules, and early hepatocellular carcinomas.

Conclusions:

Gd-EOB-DTPA-enhanced MRI provides unique anatomic and functional information unattainable with non-specific agents.
This agent improves the diagnosis of various liver conditions, including cancer.
Further research is needed to fully establish its potential in quantitative liver assessment.