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Updated: May 23, 2026

Identifying Transcription Factor Olig2 Genomic Binding Sites in Acutely Purified PDGFRα+ Cells by Low-cell Chromatin Immunoprecipitation Sequencing Analysis
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Identifying Transcription Factor Olig2 Genomic Binding Sites in Acutely Purified PDGFRα+ Cells by Low-cell Chromatin Immunoprecipitation Sequencing Analysis

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Transcription factor binding sites detection by using alignment-based approach

Ghasem Mahdevar1, Mehdi Sadeghi, Abbas Nowzari-Dalini

  • 1Department of Bioinformatics, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. mahdevar@ibb.ut.ac.ir

Journal of Theoretical Biology
|April 17, 2012
PubMed

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...