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Related Experiment Video

Updated: May 23, 2026

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing
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Microfabrication-derived DDS: From batch to individual production.

K Takada1

  • 1Department of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan.

Drug Discoveries & Therapeutics
|April 17, 2012
PubMed
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Advances in microfabrication technology enable the creation of novel microparticles. These innovations overcome limitations of traditional methods, offering improved drug delivery systems like three-layer microcapsules and self-dissolving micropiles.

Area of Science:

  • Pharmaceutical Technology
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Conventional microparticles produced via batch methods suffer from low loading efficiency, size variation, and initial burst release.
  • Traditional microparticles possess a uniform spherical structure, limiting their functionality to sustained release only.
  • Recent microfabrication technology (MFT) advances allow for individual preparation of microparticles, addressing prior limitations.

Purpose of the Study:

  • To introduce three-layer microcapsules (TLMCs) designed to overcome the limitations of conventional microparticles.
  • To highlight the enhanced functionalities of TLMCs, including sustained release, adhesion, and targeting.
  • To explore the application of MFT in developing advanced drug delivery systems, such as percutaneous preparations.

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Last Updated: May 23, 2026

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Main Methods:

  • Utilizing microfabrication technology (MFT) for the individual preparation of microparticles.
  • Designing and fabricating three-layer microcapsules (TLMCs) with distinct surface, drug-carrying, and basement layers.
  • Employing ink-jet printer nozzle technology for TLMC preparation and MFT for self-dissolving micropiles (SDMPs).

Main Results:

  • TLMCs exhibit improved drug loading efficiency, size uniformity, and controlled release profiles compared to conventional microparticles.
  • TLMCs demonstrate sustained release, adhesiveness, and targeting capabilities, expanding their functional scope.
  • MFT enables the development of SDMPs for percutaneous delivery of biopharmaceutical drugs like insulin and growth hormone.

Conclusions:

  • Microfabrication technology has significantly advanced pharmaceutical development, enabling the creation of sophisticated microparticle-based drug delivery systems.
  • TLMCs offer a promising platform for oral delivery of peptide/protein drugs and long-term injectable preparations.
  • MFT facilitates transdermal absorption of biopharmaceuticals, paving the way for innovative drug administration routes.