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Updated: May 23, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
Rhabdomyolysis
1Acute Medicine in the Intensive Care Unit, Homerton University Hospital, London E9 6SR. jfdwolff@doctors.org.uk
Abstract:
Rhabdomyolysis is the destruction of a significant amount of striated muscle, leading to disruptions in fluid balance, electrolytes and renal function. It may have either traumatic (such as crush injury) or non-traumatic causes. Diagnosis is typically made through the timely determination of the serum creatine kinase activity in a patient with a suggestive history or clinical features. Treatment is supportive, with generous intravenous hydration and correction of electrolyte abnormalities. Sometimes haemofiltration or dialysis is required, but the renal prognosis is generally good.
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