Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Nucleolus02:55

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Nuclear Protein Sorting01:34

Nuclear Protein Sorting

Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protective role of TGF-β1 (-509C>T, rs1800469) single-nucleotide polymorphism against radiation toxicities in locally advanced head and neck cancer.

Indian journal of pathology & microbiology·2026
Same author

Impact of endometrioma on iron levels and oxidative stress in the follicular fluid in women with endometriosis: a cross-sectional study.

Scientific reports·2025
Same author

Health-related quality of life (HRQoL) and its predictors among patients with Idiopathic pulmonary fibrosis attending a tertiary care setting in Southern India.

Lung India : official organ of Indian Chest Society·2025
Same author

Diagnostic Performance of Unstimulated IFN-γ (IRISA-TB) for Pleural Tuberculosis: A Prospective Study in South Africa and India.

Open forum infectious diseases·2024
Same author

Impact of SPY Fluorescence Angiography on Incidence of Ureteroenteric Stricture After Urinary Diversion.

The Journal of urology·2024
Same author

Fat containing inguinal canal mass: Thinking beyond inguinal hernia.

The American journal of the medical sciences·2024
Same journal

Molecular mechanisms of erectile dysfunction in type 1 and type 2 diabetic rats: a multiomics approach.

Asian journal of andrology·2026
Same journal

The long (GGN)n repeat tract in the androgen receptor gene exerts a negative effect on quantitative sperm parameters.

Asian journal of andrology·2026
Same journal

Exploring potential targets and mechanisms of male reproductive toxicity induced by the emerging PFAS GenX and F-53B via network toxicology, molecular docking, and in vivo validation.

Asian journal of andrology·2026
Same journal

Modifiable key factors and semen quality in men undergoing preconception evaluation: a cross-sectional study.

Asian journal of andrology·2026
Same journal

Somatic cell reprogramming into stem cells: approaches, mechanisms, and therapeutic applications.

Asian journal of andrology·2026
Same journal

A homozygous splicing mutation in CCDC39 caused multiple morphological abnormalities of the flagella in an infertile man with primary ciliary dyskinesia.

Asian journal of andrology·2026
See all related articles

Related Experiment Video

Updated: May 23, 2026

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

Nuclear morphometry, nucleomics and prostate cancer progression.

Robert W Veltri1, Christhunesa S Christudass, Sumit Isharwal

  • 1Fisher Biomarker & Biorepository Laboratory, The Brady Urological Research Institute, Baltimore, MD 21287, USA. rveltri1@jhmi.edu

Asian Journal of Andrology
|April 17, 2012
PubMed
Summary
This summary is machine-generated.

Prostate cancer (PCa) develops through multiple steps, including aging and inflammation, leading to genetic changes and uncontrolled cell growth. Understanding these molecular events aids in assessing PCa progression and management.

More Related Videos

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
07:42

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Published on: November 26, 2015

Related Experiment Videos

Last Updated: May 23, 2026

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
07:42

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Published on: November 26, 2015

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Prostate cancer (PCa) arises from a complex multistep process involving aging, inflammation, and genetic instability.
  • Key events include alterations in cell proliferation, evasion of apoptosis, and metastasis.
  • Tumor microenvironment interactions and metabolic changes play crucial roles in PCa progression.

Purpose of the Study:

  • To elucidate the multistep process of prostate cancer initiation and progression.
  • To identify critical molecular and cellular events driving PCa development.
  • To explore the role of the tumor microenvironment and cellular changes in PCa management.

Main Methods:

  • Review of molecular and cellular events in PCa pathogenesis.
  • Analysis of genetic and epigenetic alterations.
  • Examination of nuclear structure and protein changes.

Main Results:

  • PCa initiation involves aging, insults, and DNA damage, followed by progression with genetic/epigenetic changes.
  • Sustained proliferative signaling, evasion of suppressors, and metastasis are hallmarks.
  • Nuclear alterations and tumor microenvironment interactions are significant in PCa.

Conclusions:

  • Prostate cancer development is a multistep process with identifiable molecular and cellular hallmarks.
  • Quantifying these malignancy-associated events can inform disease progression assessment and management strategies.
  • Further research into PCa pathogenesis, including the tumor microenvironment, is vital for effective treatment.