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Aggressive EBV-associated lymphoproliferative disorder: a prodrome to diffuse large B-cell lymphoma?
Rashmi Batra1, Bruno C Medeiros, James L Zehnder
1Department of Pathology and Internal Medicine, Stanford University School of Medicine, Stanford, CA 94305-5324, USA.
Applied Immunohistochemistry & Molecular Morphology : AIMM
|April 17, 2012
Summary
Epstein-Barr virus (EBV) can progress from infectious mononucleosis to diffuse large B-cell lymphoma, complicated by hemophagocytic syndrome. This case highlights EBV
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Epstein-Barr virus (EBV) is a common human herpesvirus.
- EBV infection typically causes infectious mononucleosis.
- EBV is associated with various lymphoproliferative disorders.
Observation:
- A 19-year-old male presented with symptoms suggestive of infectious mononucleosis.
- Initial lymph node biopsy indicated an EBV-associated lymphoproliferative disorder.
- The patient later developed diffuse large B-cell lymphoma (DLBCL) with hemophagocytic syndrome.
Findings:
- Molecular studies revealed a clonal EBV population in the DLBCL.
- Persistent EBV viremia and elevated ferritin/soluble IL-2 receptors were noted.
- The patient showed a transient response to Rituxan therapy.
Implications:
- This case underscores the potential oncogenic role of EBV.
- EBV-associated lymphoproliferative disorders require careful monitoring.
- Understanding EBV pathogenesis is crucial for managing associated malignancies.
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