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Directing stem cell fate by controlling the affinity and density of ligand-receptor interactions at the biomaterials

Kristopher A Kilian1, Milan Mrksich

  • 1Department of Chemistry, Northwestern University, USA.

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Ligand Binding Sites02:40

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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...