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Related Experiment Video

Updated: May 23, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Published on: June 16, 2020

Interleukin 6 in systemic sclerosis and potential implications for targeted therapy.

Chayawee Muangchan1, Janet E Pope

  • 1Division of Rheumatology, Department of Medicine, Faculty of Medicine, Mahidol University, Siriraj Hospital, Bangkok, Thailand.

The Journal of Rheumatology
|April 17, 2012
PubMed
Summary

Interleukin 6 (IL-6) plays a significant role in systemic sclerosis (SSc). Research indicates IL-6 influences key cellular processes and extracellular matrix in SSc patients.

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Area of Science:

  • Rheumatology
  • Immunology
  • Cell Biology

Background:

  • Systemic sclerosis (SSc) is a complex autoimmune disease characterized by fibrosis.
  • The role of specific cytokines in SSc pathogenesis requires further elucidation.

Purpose of the Study:

  • To review the potential significance of interleukin 6 (IL-6) in the context of systemic sclerosis (SSc).
  • To synthesize current literature on IL-6's involvement in SSc.

Main Methods:

  • A comprehensive literature search was conducted using PubMed and Scopus databases.
  • Abstracts from the American College of Rheumatology and European League Against Rheumatism (2009-2011) were also included.
  • Keywords included "scleroderma," "SSc," "cytokines," "interleukins," and "interleukin 6."

Main Results:

  • Out of 416 initial reports, 44 publications were selected for review.
  • Forty of these publications suggested a significant role for IL-6 in SSc.
  • A cell interaction model was constructed to illustrate IL-6's effects.

Conclusions:

  • A strong consensus exists, with 40 out of 44 studies indicating IL-6's importance in SSc.
  • IL-6's influence extends to macrophages, fibroblasts, plasma cells, monocytes, and extracellular matrix.
  • This provides a conceptual framework for understanding IL-6's impact on SSc pathophysiology.