Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Determination of Crystal Structures01:29

Determination of Crystal Structures

In the late 1800s, the revelation that light extended beyond visible wavelengths led to the discovery of X-rays by Wilhelm Roentgen. Recognized as high-energy electromagnetic radiation with short wavelengths, X-rays prompted exploration into their interaction with crystals. Max von Laue proposed in 1912 that the periodic arrangement of atoms, ions, or molecules in crystals would cause them to diffract X-rays, a hypothesis confirmed through experiments with copper sulfate and zinc sulfide...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing variations in 3D image quality in chest CT across sites and scanners.

Medical physics·2026
Same author

Skeletal Muscle Ultrasound Radiomics and Machine Learning for the Earlier Detection of Type 2 Diabetes Mellitus.

Journal of medical ultrasound·2025
Same author

Thorax-encompassing multi-modality PET/CT deep learning model for resected lung cancer prognostication: A retrospective, multicenter study.

Medical physics·2025
Same author

Deep Rib Fracture Instance Segmentation and Classification From CT on the RibFrac Challenge.

IEEE transactions on medical imaging·2025
Same author

Fracture and Fragmentation of Vascular Calcifications by Focused Ultrasound.

Journal of cardiovascular translational research·2025
Same author

Virtual imaging trials in medicine: A brief takeaway of the lessons from the first international summit.

Medical physics·2024
Same journal

Design and realization of a sputter deposition system for the <i>in situ</i> and <i>in operando</i> use in polarized neutron reflectometry experiments: Novel capabilities.

Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment·2026
Same journal

Monte Carlo Modeling of An Experimental Benchtop L-shell X-ray Fluorescence Imaging/CT System Adopting Two Silicone Drift Detectors.

Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment·2025
Same journal

Autonomous screening of complex phase spaces using Bayesian optimization for SAXS measurements.

Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment·2025
Same journal

Integration of an electron beam ion trap source into an electrostatic accelerator for pre-clinical cancer research.

Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment·2025
Same journal

Characterization of external optical crosstalk reduction for SiPM-based scintillation detectors with an optical bandpass filter.

Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment·2025
Same journal

Cold neutron radiation dose effects on a <sup>6</sup>LiF:ZnS(Ag) neutron detector with wavelength shifting fibers and SiPM photodetector.

Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment·2024
See all related articles

Related Experiment Video

Updated: May 23, 2026

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

Detector Position Estimation for PET Scanners.

Larry Pierce1, Robert Miyaoka, Tom Lewellen

  • 1Department of Radiology, Image Research Laboratory, University of Washington, Seattle, WA, 98195.

Nuclear Instruments & Methods in Physics Research. Section A, Accelerators, Spectrometers, Detectors and Associated Equipment
|April 17, 2012
PubMed
Summary
This summary is machine-generated.

This study introduces a new method to precisely determine detector block positioning errors in Positron Emission Tomography (PET) scanners. The algorithm accurately estimates spatial errors, improving image reconstruction quality.

More Related Videos

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
10:53

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Published on: November 23, 2012

Related Experiment Videos

Last Updated: May 23, 2026

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
10:53

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Published on: November 23, 2012

Area of Science:

  • Medical Imaging
  • Nuclear Physics
  • Instrumentation

Background:

  • Positron Emission Tomography (PET) scanners rely on precise detector block alignment.
  • Inexact physical positioning of these detector blocks can lead to image artifacts and reduced quantitative accuracy.
  • Accurate calibration is crucial for reliable PET imaging.

Purpose of the Study:

  • To develop and validate a novel methodology for determining the six degrees of freedom of detector block positioning errors in PET scanners.
  • To assess the accuracy and practicality of the proposed positioning estimation algorithm.
  • To demonstrate the impact of the algorithm on the quantitative and qualitative accuracy of reconstructed PET images.

Main Methods:

  • A proof-of-concept methodology using a rotating point source over stepped axial intervals was developed.
  • Computer simulations of seven Micro Crystal Element Scanner (MiCES) PET systems with randomized positioning errors were created.
  • The positioning algorithm's performance was evaluated using virtual acquisitions of point source grids and distributed phantoms.

Main Results:

  • The algorithm accurately estimated detector block positions, achieving an average accuracy of one-seventh of the crystal pitch tangentially and one-third axially.
  • Virtual acquisitions demonstrated significant improvements in both quantitative and qualitative accuracy of reconstructed objects.
  • The method proved effective in identifying and correcting for positioning uncertainties.

Conclusions:

  • The developed estimation algorithm is a practical and accurate tool for determining scintillation detector block spatial positions in PET scanners.
  • This method has the potential to enhance the performance and reliability of PET imaging systems.
  • Improved detector positioning directly translates to better diagnostic accuracy in PET scans.