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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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[Preparation of curcumin solid dispersion and inclusion complex].

Zhen-Shen Gao1, Xiao-Li Zhang, Jian-Duo Wang

  • 1College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China. gaozhenshen@lyu.edu.cn

Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials
|April 18, 2012
PubMed
Summary

Curcumin solid dispersion with povidone k-30 (PVP k-30) significantly enhanced curcumin solubility and stability. This formulation also demonstrated superior transdermal properties, making it a promising delivery system.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Curcumin, a natural compound, suffers from poor solubility and stability.
  • Solid dispersions and inclusion complexes are strategies to improve drug delivery.

Purpose of the Study:

  • To prepare and evaluate curcumin solid dispersions and inclusion complexes.
  • To assess the stability and transdermal properties of these formulations.

Main Methods:

  • Solvent and solvent-melting methods were used for preparation with hydrophilic polymers.
  • Characterization included optical microscopy, melting point, UV-Vis spectrophotometry, and stability testing under various conditions.
  • Lipid/aqueous partition coefficients and permeation were measured.

Main Results:

  • Curcumin solid dispersion with PVP k-30 showed the highest content (81.26%) and solubility (337.59 microg/mL).
  • An oil-water distribution coefficient of 26.04 indicated good penetration properties.

Conclusions:

  • Curcumin solubility and stability can be improved using solid dispersion techniques.
  • PVP k-30 as a carrier yielded the best results for curcumin solubility and oil-water partition coefficient.