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Updated: May 23, 2026

Eye Tracking Young Children with Autism
Published on: March 27, 2012
Patterns of developmental trajectories in toddlers with autism spectrum disorder
Catherine Lord1, Rhiannon Luyster, Whitney Guthrie
1Center for Autism and the Developing Brain and Department of Psychiatry, Weill Cornell Medical College, New York Presbyterian Hospital, White Plains, NY 10605, USA. cal2028@med.cornell.edu
Insights
Early autism spectrum disorder (ASD) identification is crucial. This study tracked toddlers, revealing varied developmental trajectories and confirming the need for ongoing monitoring and standardized assessments in at-risk children.
Area of Science:
- Developmental psychology
- Pediatric neurology
- Autism spectrum disorder research
Background:
- Early identification of autism spectrum disorder (ASD) is critical for intervention.
- Understanding developmental trajectories in toddlers at risk for ASD is essential.
Purpose of the Study:
- To longitudinally track toddlers referred for autism risk.
- To utilize frequent, standardized observational measures from 18 to 36 months of age.
Main Methods:
- Sixty-five referred children and 13 from other projects were assessed every 2 months.
- Standardized assessments and clinical judgments were performed by a consistent examiner.
- Examiners blind to previous scores conducted assessments every 6 months.
Main Results:
- 48 children received an autism spectrum disorder (ASD) diagnosis; 30 did not.
- Four trajectory classes were identified using Autism Diagnostic Observation Schedule (ADOS) scores: severe persistent (21%), worsening (21%), improving (19%), and nonspectrum (40%).
- Trajectory classes differed in verbal and nonverbal mental ages; diagnostic groups differed on Autism Diagnostic Interview-Revised (ADI-R) scores.
Conclusions:
- Findings align with studies on infant siblings of children with and without autism.
- Results highlight significant variability in early developmental trajectories for children at risk of ASD.
- Early identification, regular monitoring, and standardized assessments are vital for young children suspected of having ASD.
Objective:
Our objective was to follow toddlers referred for risk of autism, using standardized observational measures administered frequently from age 18 months to age 36 months.
Method:
Sixty-five children who were consecutive referrals and 13 children from other research projects were seen approximately every 2 months, from age 18 months to age 36 months, for standardized assessments and clinical judgments by the same examiner and every 6 months by an examiner blind to previous scores.
Results:
Thirty children never received an autism spectrum disorder (ASD) diagnosis; 48 children (all referrals) received at least 1 diagnosis of ASD. The best trajectory typology, using Autism Diagnostic Observation Schedule (ADOS) scores, revealed 4 trajectory classes with high probabilities for fit to the most likely class: severe persistent (21%), worsening (21%), improving (19%), and nonspectrum (40%). Classes differed by trajectories in verbal and nonverbal mental ages; never-ever ASD groups differed on Autism Diagnostic Interview-Revised (ADI-R) domain scores and clinician judgments, but improving-worsening trajectory groups did not.
Conclusions:
The results replicated the findings from studies of infants whose siblings have autism and infants whose siblings do not have autism, suggesting variability in early trajectories and supporting the need for early identification, regular monitoring, and standardized assessments of young children suspected of having ASD.
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