Patterns of developmental trajectories in toddlers with autism spectrum disorder

Catherine Lord1, Rhiannon Luyster, Whitney Guthrie

  • 1Center for Autism and the Developing Brain and Department of Psychiatry, Weill Cornell Medical College, New York Presbyterian Hospital, White Plains, NY 10605, USA. cal2028@med.cornell.edu

Insights

Early autism spectrum disorder (ASD) identification is crucial. This study tracked toddlers, revealing varied developmental trajectories and confirming the need for ongoing monitoring and standardized assessments in at-risk children.

Area of Science:

  • Developmental psychology
  • Pediatric neurology
  • Autism spectrum disorder research

Background:

  • Early identification of autism spectrum disorder (ASD) is critical for intervention.
  • Understanding developmental trajectories in toddlers at risk for ASD is essential.

Purpose of the Study:

  • To longitudinally track toddlers referred for autism risk.
  • To utilize frequent, standardized observational measures from 18 to 36 months of age.

Main Methods:

  • Sixty-five referred children and 13 from other projects were assessed every 2 months.
  • Standardized assessments and clinical judgments were performed by a consistent examiner.
  • Examiners blind to previous scores conducted assessments every 6 months.

Main Results:

  • 48 children received an autism spectrum disorder (ASD) diagnosis; 30 did not.
  • Four trajectory classes were identified using Autism Diagnostic Observation Schedule (ADOS) scores: severe persistent (21%), worsening (21%), improving (19%), and nonspectrum (40%).
  • Trajectory classes differed in verbal and nonverbal mental ages; diagnostic groups differed on Autism Diagnostic Interview-Revised (ADI-R) scores.

Conclusions:

  • Findings align with studies on infant siblings of children with and without autism.
  • Results highlight significant variability in early developmental trajectories for children at risk of ASD.
  • Early identification, regular monitoring, and standardized assessments are vital for young children suspected of having ASD.
Abstract

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