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Related Experiment Video

Updated: May 23, 2026

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CD36 promotes adipocyte differentiation and adipogenesis.

Valerie Christiaens1, Matthias Van Hul, H Roger Lijnen

  • 1Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.

Biochimica Et Biophysica Acta
|April 18, 2012
PubMed
Summary

CD36 (scavenger receptor) promotes fat cell (adipocyte) development. Silencing CD36 impaired adipogenesis in vitro and reduced fat tissue formation and body weight in vivo, highlighting its role in metabolic health.

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Area of Science:

  • Molecular Biology
  • Metabolic Disorders
  • Adipogenesis Research

Background:

  • CD36 is a membrane glycoprotein implicated in metabolic disorders such as obesity.
  • Obesity is a significant global health concern requiring further investigation into its underlying mechanisms.

Purpose of the Study:

  • To investigate the functional role of the scavenger receptor CD36 in adipocyte differentiation and adipogenesis.
  • To determine the impact of CD36 on fat tissue formation and body weight regulation.

Main Methods:

  • In vitro studies using 3T3-F442A preadipocytes to assess CD36 expression during differentiation.
  • CD36 gene silencing in preadipocytes and assessment of adipogenesis markers and Oil Red O staining.
  • In vivo studies involving NUDE mice and CD36-deficient mice in obesity models.

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Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
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Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Published on: February 3, 2023

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Last Updated: May 23, 2026

Robust Differentiation of Human iPSCs into a Pure Population of Adipocytes to Study Adipocyte-Associated Disorders
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Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
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Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

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Main Results:

  • CD36 expression was upregulated during adipocyte differentiation, and its silencing impaired this process.
  • CD36 gene silencing reduced de novo fat pad formation, adipocyte size, and adipose tissue mass.
  • CD36 deficiency in mice led to significantly lower body weight and adipose tissue mass in a diet-induced obesity model.

Conclusions:

  • CD36 plays a crucial functional role in promoting adipogenesis both in vitro and in vivo.
  • These findings support CD36 as a potential therapeutic target for metabolic disorders like obesity.