Targeted therapy of multiple myeloma
1Mayo Clinic, Division of Hematology, 200 First Street SW, Rochester, MN 55905, USA. kyle.robert@mayo.edu
Hematology (Amsterdam, Netherlands)
|April 18, 2012
Summary
Multiple myeloma diagnosis requires specific criteria. Current treatments for eligible patients include novel agents with dexamethasone, with stem cell collection for autologous stem cell transplant (ASCT).
Area of Science:
- Hematology
- Oncology
- Clinical Medicine
Background:
- Multiple myeloma is a plasma cell proliferative disorder.
- Diagnosis requires monoclonal bone marrow plasma cells, a monoclonal (M) protein, and evidence of end-organ damage.
Purpose of the Study:
- To outline the diagnostic criteria for multiple myeloma.
- To describe current initial therapeutic strategies for transplant-eligible and ineligible patients.
- To highlight emerging agents in clinical trials.
Main Methods:
- Review of diagnostic criteria for multiple myeloma.
- Summary of current first-line treatment regimens.
- Overview of agents in active clinical trials.
Main Results:
- Standard diagnostic criteria involve monoclonal proteins and end-organ damage.
- Transplant-eligible patients receive novel agents (thalidomide, bortezomib, lenalidomide) with dexamethasone, with stem cell collection for ASCT.
- Transplant-ineligible patients receive melphalan and prednisone plus novel agents.
Conclusions:
- Treatment strategies are tailored based on autologous stem cell transplant eligibility.
- Ongoing research is exploring over 100 novel agents, with carfilzomib and pomalidomide showing promise.
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