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Published on: April 13, 2017
Neuroinflammation: a need to understand microglia as resident cells of the developing brain
1National Toxicology Program Laboratory, National Institute of Environmental Health Sciences, PO Box 12233, MD C1-04, Research Triangle Park, NC 27709, USA. harry@niehs.nih.gov
Abstract:
Neuroinflammation and microglia as the resident immune cells of the brain has garnered a significant amount of interest with regards to brain injury and neurotoxicology. Much of this interest and research has been focused on responses in the adult brain with little attention paid to the role of these cells during development. The available data suggests that one must view microglia and their processes during development somewhat differently. In addition, modification to microglia during development may lay a framework for subtle to significant changes in the susceptibility of the mature brain to secondary insults. A number of these point are now being raised for consideration.
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