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Anorexia Nervosa

Anorexia Nervosa

Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...

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Updated: May 23, 2026

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

Published on: August 23, 2018

Marrow fat and preadipocyte factor-1 levels decrease with recovery in women with anorexia nervosa.

Pouneh K Fazeli¹, Miriam A Bredella, Lauren Freedman

¹Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. pkfazeli@partners.org.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research

|April 18, 2012

Summary

This summary is machine-generated.

Marrow fat and preadipocyte factor-1 levels decrease with recovery from anorexia nervosa. These findings suggest preadipocyte factor-1 has different effects depending on nutritional status.

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Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

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Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

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Published on: May 19, 2023

Area of Science:

Endocrinology
Bone Metabolism
Nutritional Science

Background:

Women with anorexia nervosa (AN) exhibit increased marrow fat mass, inversely related to bone mineral density (BMD).
It remains unknown if marrow fat mass persists or resolves upon recovery from AN.

Purpose of the Study:

To investigate marrow fat changes in women recovered from AN (AN-R).
To examine the relationship between preadipocyte factor-1 (Pref-1), fat depots, and BMD in AN, AN-R, and healthy controls (HC).

Main Methods:

Studied 29 women: 14 with AN or AN-R and 15 HC.
Measured L4 vertebral and femoral marrow adipose tissue (MAT) using 1H-magnetic resonance spectroscopy.
Assessed BMD (spine, hip, total body) via DXA and measured serum Pref-1 and leptin levels.

Main Results:

MAT of the L4 vertebra was significantly lower in AN-R compared to AN and comparable to HC.
Serum Pref-1 levels were also significantly lower in AN-R compared to AN and comparable to HC.
Pref-1 positively correlated with L4 MAT in AN, but inversely correlated in HC.

Conclusions:

Marrow adipose tissue and Pref-1 levels decrease with recovery from anorexia nervosa.
Pref-1 may exert differential effects in states of nutritional deprivation versus sufficiency.