Related Experiment Video
Updated: May 23, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Clinical implication of 14-3-3 epsilon expression in gastric cancer
Mariana Ferreira Leal1, Danielle Queiroz Calcagno, Sâmia Demachki
1Genetics Division, Department of Morphology and Genetic, Federal University of São Paulo, São Paulo, Brazil. mariana.morf@epm.br
Aim:
To evaluate for the first time the protein and mRNA expression of 14-3-3ε in gastric carcinogenesis.
Methods:
14-3-3ε protein expression was determined by western blotting, and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples.
Results:
Authors observed a significant reduction of 14-3-3ε protein expression in gastric cancer (GC) samples compared to their matched non-neoplastic tissue. Reduced levels of 14-3-3ε were also associated with diffuse-type GC and early-onset of this pathology. Our data suggest that reduced 14-3-3ε may have a role in gastric carcinogenesis process.
Conclusion:
Our results reveal that the reduced 14-3-3ε expression in GC and investigation of 14-3-3ε interaction partners may help to elucidate the carcinogenesis process.
