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Published on: May 22, 2019
Homocysteine as a potential biochemical marker for depression in elderly stroke survivors
Michaela C Pascoe1, Sheila G Crewther, Leeanne M Carey
1Brain Sciences Institute, Swinburne University, Melbourne, Australia.
Background:
Elderly stroke survivors have been reported to be at risk of malnutrition and depression. Vitamin B-related metabolites such as methylmalonic acid and homocysteine have been implicated in depression.
Objective:
We conducted a study exploring the relationship between homocysteine and post-stroke depression.
Design:
THREE METHODOLOGIES WERE USED: Observational cohort study of elderly Swedish patients (n=149) 1.5 years post-stroke, assessed using Diagnostic and Statistical Manual of Mental Disorders, Montgomery Åsberg Depression Rating Scale and serum blood levels of methylmalonic acid and homocysteine.
Results:
Homocysteine significantly correlated with depressive symptomatology in stroke survivors (β=0.18*). Individuals with abnormal levels of methylmalonic acid and homocysteine were almost twice more likely to show depressive symptomatology than those with normal levels (depressive symptoms 22%; no depressive symptoms 12%). Comparison of methylmalonic acid and homocysteine levels with literature data showed fewer stroke survivors had vitamin deficiency than did reference individuals (normal range 66%; elevated 34%).
Conclusions:
Homocysteine is significantly associated with depressive symptomatology in elderly Swedish stroke survivors.
