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Updated: May 23, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
Molecular pathways of notch signaling in vascular smooth muscle cells
Joshua Boucher1, Thomas Gridley, Lucy Liaw
1Center for Molecular Medicine, Maine Medical Center Research Institute Scarborough, ME, USA.
Abstract:
Notch signaling in the cardiovascular system is important during embryonic development, vascular repair of injury, and vascular pathology in humans. The vascular smooth muscle cell (VSMC) expresses multiple Notch receptors throughout its life cycle, and responds to Notch ligands as a regulatory mechanism of differentiation, recruitment to growing vessels, and maturation. The goal of this review is to provide an overview of the current understanding of the molecular basis for Notch regulation of VSMC phenotype. Further, we will explore Notch interaction with other signaling pathways important in VSMC.
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