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Published on: September 25, 2019
Hepatitis C virus cryoglobulinemia and non-hodgkin lymphoma
1Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, IR Iran. zjadali@razi.tums.ac.ir and zjadali@yahoo.co.uk
Context:
On the strength of epidemiological data,biological studies, and clinical findings, hepatitis C virus appears to be involved in the pathogenesis of a proportion of patients with non-Hodgkin lymphoma and cryoglobulinemia.
Objectives:
The aim of this paper is to review the published literature focused on the current knowledge concerning hepatitis C virus and its potential role in the production of non-Hodgkin lymphoma and cryoglobulinemia in susceptible individuals.
Evidence Acquisition:
In this review, databases such as pubMed, embase, ISI, and Iranian databases including Iranmedex, and SID were searched.
Results:
The results of this review indicate that HCV infection may be a likely cause of various B cell dysregulation disorders such as non-Hodgkin lymphoma and cryoglobulinemia.
Conclusion:
Based on current findings, it has been hypothesized that NHL and cryoglobulinemia in HCV infection may have an immune-mediated pathogenesis. In HCV infected patients, we showed an elevated risk of these two diseases. These finding suggested a possible role for chronic hepatitis C in the pathogenesis of NHL and cryoglobulinemia.
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