Related Experiment Video

Updated: May 23, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Regulation of p53 stability and apoptosis by a ROR agonist

Yongjun Wang1, Laura A Solt, Douglas J Kojetin

  • 1The Scripps Research Institute, Jupiter, Florida, United States of America.

Plos One
|April 18, 2012
PubMed

Insights

Activating the RORα receptor with SR1078 stabilizes p53 protein, inducing cancer cell death. This discovery offers a new therapeutic strategy targeting RORα for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Endocrinology

Background:

  • p53 protein activation is a key strategy for anti-cancer drug development.
  • The orphan nuclear receptor RORα's role in cancer is not fully understood.

Purpose of the Study:

  • To investigate a novel mechanism for p53 stabilization through RORα activation.
  • To evaluate the anti-cancer potential of synthetic ROR agonists.

Main Methods:

  • Treatment of cancer cells with the synthetic ROR agonist SR1078.
  • Analysis of p53 protein levels and apoptosis induction.

Main Results:

  • SR1078 treatment led to significant p53 protein stabilization.
  • SR1078 effectively induced apoptosis in cancer cells.

Conclusions:

  • Activation of RORα by synthetic agonists like SR1078 represents a novel pathway for cancer therapy.
  • Synthetic ROR agonists show promise as anti-cancer agents by stabilizing p53.

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