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Updated: May 23, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
[Safety concentration of genotoxic carcinogens in water pollution accident based on human health risk]
Jin-Hong Luo1, Bing-Hui Zheng, Qing Fu
1School of Resource and Environmental Sciences, East China Normal University, Shanghai 200062, China. ljhgl2002@163.com
Abstract:
It was an urgent problem to determine short-term exposure safety concentration of genetic carcinogens in water pollution accident in China. Based on the hypothesis that the relationship between exposure dosage and carcinogenic risk was linear, the calculation process of genetic carcinogens safety concentration was put forwarded, and the method using life-time exposed safety concentration to calculate short-term exposure safety concentration was set up. Based on the statistical result of water pollution accident occurred in china during 2000-2010, arsenic was a major characteristic contaminate in water pollution accident. According to the method of short-term exposure safety concentration of genotoxic carcinogens, the safety concentration of arsenic was 0.5 mg x L(-1), it showed that the method was feasible in emergence management of water pollution accident.
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