Related Experiment Video
Updated: May 23, 2026

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
Published on: April 11, 2012
[Fibrodysplasia ossificans progressiva syndrome. Report of three cases]
G Macías-Hernández1, J L Campos-Macías
1Servicio de Ortopedia, Hospital Aranda de la Parra, León Gto.
Unlabelled:
Fibrodysplasia ossificans gressiva (FOP) syndrome is a very rare connective tissue disease characterized clinically by the progressive ossification of the soft tissues, usually with hallux malformation.
Material And Methods:
Three patients diagnosed with FOP during 2006 were clinically, radiographically and tomographically assessed.
Results:
Three female patients ages 4, 6 and 12 years old with hallux deformity and indurated tumors of the trunk, neck and shoulders.
Conclusion:
FOP is a rare autosomal dominant genetic disease that manifests itself with ossification of the soft tissues, which progressively limits joint and trunk mobility.
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Formation by Endochondral Ossification
Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Disorders of the Skeletal Muscle
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Spongy Bone
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
