Related Experiment Video
Updated: May 23, 2026

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
Published on: January 19, 2019
New conjugated polymers for photoinduced unwinding of DNA supercoiling and gene regulation
Gaomai Yang1, Huanxiang Yuan, Chunlei Zhu
1Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences , Beijing, 100190, PR China.
Abstract:
Three cationic polythiophene derivatives (P1, P2, P3) were synthesized and characterized. Under white light irradiation (400-800 nm), they sensitize oxygen molecule in the surrounding to generate reactive oxygen species (ROS) that can efficiently unwind the supercoiled DNA in vitro. Further study shows that this relaxation of the DNA supercoiling results in the decrease of gene (pCX-EGFP plasmid) expression level. The ability of these conjugated polymers for regulating gene expression will add a new dimension to the function of conjugated polymers.
More Related Videos
Related Concept Videos
DNA Topoisomerases
Types and Mechanism of action
Topoisomerases are divided into two main types. Type I...
Cooperative Binding of Transcription Regulators
Single-Strand DNA Binding Proteins
Inhibitors of Bacterial DNA Synthesis
DNA Helicases

