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Updated: May 23, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
Published on: December 22, 2020
Fibroblasts--a key host cell type in tumor initiation, progression, and metastasis
Carina Strell1, Helene Rundqvist, Arne Ostman
1Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Abstract:
Tumor initiation, growth, invasion, and metastasis occur as a consequence of a complex interplay between the host environment and cancer cells. Fibroblasts are now recognized as a key host cell type involved in host-cancer signaling. This review discusses some recent studies that highlight the roles of fibroblasts in tumor initiation, early progression, invasion, and metastasis. Some clinical studies describing the prognostic significance of fibroblast-derived markers and signatures are also discussed.
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