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Related Experiment Video

Updated: May 23, 2026

Reduced Procedure Time and Variability with Active Esophageal Cooling During Radiofrequency Ablation for Atrial Fibrillation
04:58

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Published on: August 25, 2022

Bimodal electric tissue ablation (BETA) compared with the Cool-Tip RFA system.

Leong Ung Tiong1, John B F Field, Guy J Maddern

  • 1University of Adelaide Discipline of Surgery, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.

ANZ Journal of Surgery
|April 19, 2012
PubMed
Summary

Bimodal electric tissue ablation (BETA) significantly increases ablation size compared to standard radiofrequency ablation (RFA). BETA and electrochemical treatment (ECT)/RFA enhance RFA efficacy for larger tissue ablations.

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Area of Science:

  • Medical Devices
  • Surgical Technology
  • Electrophysiology

Background:

  • Bimodal electric tissue ablation (BETA) combines electrolysis with radiofrequency ablation (RFA).
  • Investigates BETA's efficacy with the Cool-Tip RF system.
  • Compares BETA to electrochemical treatment (ECT)/RFA and standard RFA.

Purpose of the Study:

  • To evaluate if BETA enhances RFA efficacy for larger tissue ablations.
  • To compare BETA with ECT/RFA and RFA alone.
  • To assess BETA's potential for treating larger liver tumors.

Main Methods:

  • Utilized a Cool-Tip RF system in a pig liver model.
  • Tested three ablation techniques: RFA, BETA, and ECT/RFA.
  • Measured ablation sizes in three dimensions.

Main Results:

  • BETA and ECT/RFA produced significantly larger ablations than standard RFA (P < 0.001).
  • BETA resulted in larger ablations compared to ECT/RFA (P < 0.001).

Conclusions:

  • BETA improves Cool-Tip RF system efficacy for larger ablations.
  • Increased tissue hydration in BETA enhances electrical energy delivery and delays desiccation.
  • BETA shows potential for more effective treatment of larger liver tumors than RFA.