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A 1.5 Hour Procedure for Identification of Enterococcus Species Directly from Blood Cultures
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Clinical streptococci and their sensitivity to enterocins produced by different strains of the species Enterococcus

Anna Kandricáková1, Andrea Lauková

  • 1Slovak Academy of Sciences, Institute of Animal Physiology, Košice, Slovakia.

Acta Microbiologica Et Immunologica Hungarica
|April 19, 2012
PubMed

Insights

This study explored enterocins (Ent) as a novel treatment for acute otitis media (AOM) in children. Enterocins showed antimicrobial activity against Streptococcus pneumoniae and Streptococcus pyogenes, suggesting a potential alternative to antibiotics.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Acute otitis media (AOM) is a common childhood infection caused by Streptococcus pneumoniae and Streptococcus pyogenes.
  • Antibiotic resistance in these pathogens necessitates the development of alternative treatments for AOM.

Purpose of the Study:

  • To investigate the in vitro sensitivity of Streptococcus pneumoniae and Streptococcus pyogenes isolated from AOM to enterocins.
  • To evaluate enterocins as a potential therapeutic agent against AOM-causing bacteria.

Main Methods:

  • In vitro testing of streptococci isolated from AOM against enterocins produced by Enterococcus faecium strains.
  • Determination of bacterial sensitivity and inhibition zones for various enterocins.

Main Results:

  • Streptococcus pneumoniae strains showed sensitivity to at least one enterocin, with one strain sensitive to five.
  • Streptococcus pyogenes strains demonstrated sensitivity to enterocins, with some inhibited by Enterocin A (P).
  • Most enterocins inhibited the growth of tested streptococci at concentrations between 100 and 3,200 AU/ml, with Streptococcus pyogenes being more sensitive than Streptococcus pneumoniae.

Conclusions:

  • Enterocins exhibit antimicrobial activity against key AOM pathogens, Streptococcus pneumoniae and Streptococcus pyogenes.
  • Enterocins represent a promising alternative or adjunct therapy for AOM, warranting further investigation.
  • The findings suggest a novel application for enterocins in combating antibiotic-resistant bacterial infections.

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