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Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:

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Related Experiment Video

Updated: May 23, 2026

Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition
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Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition

Published on: June 16, 2019

Modeling human hematopoietic cell development from pluripotent stem cells.

Melanie D Kardel1, Connie J Eaves

  • 1Terry Fox Laboratory, British Columbia Cancer Agency and the Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

Experimental Hematology
|April 19, 2012
PubMed
Summary

Researchers are developing in vitro systems using human stem cells to study hematopoietic cell development. This approach addresses limitations of in vivo mouse models for understanding human-specific developmental processes.

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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
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Direct Induction of Hemogenic Endothelium and Blood by Overexpression of Transcription Factors in Human Pluripotent Stem Cells
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Direct Induction of Hemogenic Endothelium and Blood by Overexpression of Transcription Factors in Human Pluripotent Stem Cells

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Last Updated: May 23, 2026

Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition
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Published on: June 16, 2019

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

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Direct Induction of Hemogenic Endothelium and Blood by Overexpression of Transcription Factors in Human Pluripotent Stem Cells
08:14

Direct Induction of Hemogenic Endothelium and Blood by Overexpression of Transcription Factors in Human Pluripotent Stem Cells

Published on: December 3, 2015

Area of Science:

  • Hematopoiesis
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Hematopoietic cell generation is crucial for development and has clinical implications.
  • Mouse models offer insights but cannot fully capture human-specific developmental features.
  • Studying human development in vivo is ethically and practically challenging.

Purpose of the Study:

  • To review advancements in defined, quantitative in vitro systems for studying human hematopoietic development.
  • To bridge the gap between knowledge from fetal and mouse embryonic stem cell studies and human development.
  • To explore human embryonic stem cells and induced pluripotent stem cells as models for hematopoiesis.

Main Methods:

  • Review of recent literature on defined and quantitative systems for hematopoietic development.
  • Analysis of in vitro models using human embryonic stem cells and induced pluripotent stem cells.
  • Comparison of findings with established knowledge from fetal and mouse models.

Main Results:

  • Development of defined and quantitative in vitro systems is progressing.
  • Human stem cells offer a viable alternative for studying human-specific hematopoietic development.
  • These systems allow for detailed analysis of developmental questions previously inaccessible in vivo.

Conclusions:

  • In vitro systems using human stem cells are essential for understanding human hematopoietic development.
  • These models complement existing knowledge from mouse studies and fetal development.
  • Further development of these systems will advance both biological understanding and clinical applications.