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NMDA-dependent switch of proBDNF actions on developing GABAergic synapses

Anais Langlois1, Diabe Diabira, Nadine Ferrand

  • 1Institut National de la Santé et de la Recherche Médicale Unité 901, Marseille 13009, France.

Cerebral Cortex (New York, N.Y. : 1991)
|April 19, 2012
PubMed
Summary

Brain-derived neurotrophic factor precursor (proBDNF) bidirectionally controls GABAergic synapses. NMDA receptor activity dictates whether proBDNF potentiates or depresses these crucial neuronal connections.

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