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Manzamines: a potential for novel cures.

Mona Radwan1, Amro Hanora, Sherief Khalifa

  • 1Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Cell Cycle (Georgetown, Tex.)
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PubMed
Summary
This summary is machine-generated.

Manzamine marine alkaloids, potent against malaria, cancer, and infections, may originate from Red Sea microbes. Over 80 related compounds have been identified from marine sponges.

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Area of Science:

  • Marine natural products chemistry
  • Medicinal chemistry
  • Microbial biochemistry

Background:

  • Manzamines are a unique class of marine alkaloids featuring complex tetra- or pentacyclic structures.
  • These compounds exhibit diverse bioactivities, including anticancer, anti-infective, and anti-inflammatory properties.
  • Manzamine alkaloids show particular promise against malaria, with higher potency than existing drugs like chloroquine and artemisinin.

Purpose of the Study:

  • To review the biological activities of manzamine alkaloids.
  • To explore the potential microbial origin of manzamines.
  • To highlight the Red Sea as a prospective source for manzamine discovery.

Main Methods:

  • Literature review of marine natural products.
  • Analysis of isolated manzamine alkaloids and their bioactivities.
  • Investigation of sponge families and geographical distribution.

Main Results:

  • Over 80 manzamine-related alkaloids identified from 16+ sponge species across five families.
  • Significant antimalarial activity demonstrated, exceeding that of chloroquine and artemisinin.
  • Distribution suggests a possible microbial biosynthesis pathway.

Conclusions:

  • Manzamine alkaloids represent a promising class of natural products with significant therapeutic potential, especially for malaria.
  • The Red Sea microbial communities are a potential untapped resource for novel manzamine discovery.
  • Further research into biosynthetic gene clusters could unlock new manzamine production strategies.