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Related Concept Videos

Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Allergic Reactions02:06

Allergic Reactions

Overview
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Related Experiment Video

Updated: May 23, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Exercise inhibits allergic lung inflammation.

A C D Silva1, R P Vieira, M Nisiyama

  • 1Physical Therapy, University of São Paulo, Sao Paulo, Brazil.

International Journal of Sports Medicine
|April 19, 2012
PubMed
Summary
This summary is machine-generated.

Aerobic conditioning before and during allergic sensitization effectively reduces airway inflammation and Th2 cytokine production. This approach also lowers allergen-specific IgE and IgG1 antibody levels in mice.

Related Experiment Videos

Last Updated: May 23, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Exercise Physiology

Background:

  • Allergic airway inflammation is a significant health concern.
  • Aerobic conditioning (AC) post-sensitization mitigates allergic inflammation.
  • The impact of pre- and during-sensitization AC on airway inflammation remains unclear.

Purpose of the Study:

  • To investigate the effects of aerobic conditioning performed before and during allergic sensitization on airway inflammation in a mouse model.
  • To evaluate the influence of this AC timing on immune responses and airway remodeling.

Main Methods:

  • Mice were divided into Control, AC, Ovalbumin (OVA) sensitization, and AC + OVA groups.
  • Treadmill training constituted the AC intervention.
  • Evaluations included peribronchial inflammation, OVA-specific IgE and IgG1 titers, Th1/Th2 cytokine expression, and airway remodeling markers.

Main Results:

  • AC before and during sensitization inhibited OVA-induced eosinophil and lymphocyte migration to airways.
  • Significant reductions in IgE and IgG1 titers were observed.
  • Expression of Th2 cytokines, ICAM-1, VCAM-1, RANTES, TGF-β, and VEGF decreased.
  • Airway remodeling was notably reduced in the AC + OVA group.

Conclusions:

  • Aerobic conditioning initiated before and continued during allergic sensitization effectively inhibits allergic airway inflammation.
  • This timing of AC suppresses Th2 cytokine production and allergen-specific antibody responses.
  • The findings suggest a potential prophylactic role for early aerobic conditioning in managing allergic airway diseases.