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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Tissue Transplantation01:24

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
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Oogenesis02:07

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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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The two main cell types that...

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Related Experiment Video

Updated: May 23, 2026

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
06:49

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice

Published on: February 12, 2018

How does bone marrow transplantation affect ovarian function and fertility?

Pascale Jadoul1, Jacques Donnez

  • 1Université Catholique de Louvain, Institut de Recherche Experimentale et Clinique, Unité de Recherche GYNE, Department of Gynecology, Université Catholique de Louvain, Brussels, Belgium. pascale.jadoul@uclouvain.be

Current Opinion in Obstetrics & Gynecology
|April 19, 2012
PubMed
Summary

Bone marrow transplantation (BMT) poses a high risk of ovarian damage and premature ovarian failure (POF) in women. Fertility preservation options are crucial for women undergoing BMT.

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Fertility Preservation in Patients with Severe Ovarian Dysfunction
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Fertility Preservation in Patients with Severe Ovarian Dysfunction

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Related Experiment Videos

Last Updated: May 23, 2026

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
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Published on: February 12, 2018

Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery
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Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery

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Fertility Preservation in Patients with Severe Ovarian Dysfunction
12:03

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Published on: March 25, 2021

Area of Science:

  • Reproductive Medicine
  • Hematology
  • Oncology

Background:

  • Bone marrow transplantation (BMT) is a critical treatment for various hematologic and oncologic conditions.
  • Gonadal toxicity, particularly ovarian damage, is a significant concern for women undergoing BMT.
  • Infertility is a common and distressing consequence of BMT-related gonadal toxicity.

Purpose of the Study:

  • To review the existing literature on the gonadal toxicity of BMT in women.
  • To identify and discuss available preventive and curative strategies for infertility in women facing BMT.
  • To highlight the importance of fertility preservation for female BMT patients.

Main Methods:

  • Comprehensive literature review of studies on BMT and female gonadal function.
  • Analysis of reported outcomes regarding ovarian function, pregnancy rates, and premature ovarian failure (POF).
  • Evaluation of fertility preservation techniques relevant to female BMT recipients.

Main Results:

  • The precise incidence of ovarian damage post-BMT is challenging to ascertain due to variable study designs and endpoints.
  • The risk of premature ovarian failure (POF) following BMT is notably high, escalating with patient age and total body irradiation conditioning.
  • Fertility preservation methods including embryo, oocyte, and ovarian cortex cryopreservation are effective and recommended.

Conclusions:

  • Despite limited long-term follow-up data in large cohorts, the risk of ovarian damage and POF after BMT is substantial.
  • Fertility preservation options must be proactively discussed with all female patients scheduled for BMT.
  • Early and informed discussion of fertility preservation is essential for reproductive health in BMT survivors.