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Prohemostatic treatment in cardiac surgery

Jerrold H Levy1, Roman M Sniecinski

  • 1Department of Anesthesiology, Emory University School of Medicine and Emory Healthcare, Atlanta, Georgia 30322, USA. Jlevy01@emory.edu

Seminars in Thrombosis and Hemostasis
|April 19, 2012
PubMed

Insights

Cardiac surgery patients often experience coagulopathy from various factors. This review covers pharmacological agents like antifibrinolytics and prohemostatic therapies to manage bleeding and reduce transfusions.

Area of Science:

  • Cardiovascular Medicine
  • Hematology

Background:

  • Cardiac surgery patients present complex coagulopathy beyond blood loss.
  • Factors include hemodilution, inflammation, and cardiopulmonary bypass-induced hemostatic activation.
  • These factors offer therapeutic intervention targets.

Purpose of the Study:

  • To review pharmacological agents for managing coagulopathy in cardiac surgery.
  • To discuss strategies for reducing allogeneic blood transfusions.

Main Methods:

  • Literature review of pharmacological agents used in cardiac surgery.
  • Discussion of antifibrinolytics, prohemostatic agents, and topical agents.

Main Results:

  • Multiple agents exist to manage bleeding and coagulation.
  • Preemptive and prohemostatic strategies are employed.

Conclusions:

  • Pharmacological interventions are crucial for managing coagulopathy in cardiac surgery.
  • Targeting specific hemostatic pathways can reduce transfusion needs.

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