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Updated: May 23, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
[Extrahepatic cholangiocarcinoma: current state of palliation therapy]
G W Wolkersdörfer1, F Berr, C Nawara
1Paracelsus Medizinische Privatuniversität, Universitätsklinik für Innere Medizin I, Salzburg, Österreich. g.wolkersdoerfer@salk.at
Introduction:
Decompression of bile ducts is the priority objective in the non-curative stage of hilar cholangiocarcinoma. Only this will prevent or slow down infectious complications and secondary biliary cirrhosis thereby sustaining the quality of life. KEY STATEMENTS: At present, photodynamic therapy combined with insertion of an endoprosthesis seems to be best documented and most appropriate therapy.
Methods:
Data from a selective literature search combined with our clinical experience were evaluated.
Conclusions:
Therapeutic measures should match the dissemination and stage of the tumor: in locally advanced or progressing disease (stage III) a local ablating therapy, in systemically progressing disease (stage IV) systemic chemotherapy should be utilised.
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