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The use and tolerability of Crotalidae Polyvalent Immune FAB (Ovine) in pediatric envenomations

Henry C Farrar1, Taylor Grayham, Branson Bolden

  • 1University of Arkansas for Medical Sciences, Little Rock, AR, USA. farrarhank@uams.edu

Clinical Pediatrics
|April 19, 2012
PubMed

Insights

Crotalidae Polyvalent Immune FAB-Ovine (CroFab) is generally safe for children with snakebites. Adverse reactions were mild and did not prevent further use, indicating good tolerability in pediatric patients.

Area of Science:

  • Toxicology
  • Pediatric Medicine
  • Pharmacology

Background:

  • Limited data exist on Crotalidae Polyvalent Immune FAB-Ovine (CroFab) use in pediatric crotalid envenomations.
  • Assessing the safety and tolerability of CroFab in children is crucial for effective snakebite management.

Purpose of the Study:

  • To evaluate the safety and tolerability of CroFab in a pediatric population.
  • To analyze adverse drug reactions associated with CroFab administration in children.

Main Methods:

  • Retrospective chart review of pediatric patients admitted for snakebite over an 8-year period.
  • Analysis of data from 82 pediatric patients who received CroFab for crotalid envenomations.

Main Results:

  • Children receiving CroFab often had bites to extremities and more severe envenomations, indicated by longer hospital stays and increased need for surgery.
  • Adverse drug reactions occurred in 7.3% of pediatric patients, presenting as mild allergic symptoms.
  • Reactions were manageable with minimal intervention and did not preclude further CroFab use.

Conclusions:

  • Crotalidae Polyvalent Immune FAB-Ovine (CroFab) is typically well-tolerated in pediatric patients.
  • The safety profile of CroFab supports its use in managing crotalid envenomations in children.
  • Further research may explore optimal dosing and long-term outcomes in pediatric populations.

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