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Updated: May 23, 2026

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Ric-8: different cellular roles for a heterotrimeric G-protein GEF
M V Hinrichs1, M Torrejón, M Montecino
1Faculty of Biological Sciences, Department of Biochemistry and Molecular Biology, University of Concepción, Concepción, Chile.
Abstract:
Signaling via heterotrimeric G-proteins is evoked by agonist-mediated stimulation of seven transmembrane spanning receptors (GPCRs). During the last decade it has become apparent that Gα subunits can be activated by receptor-independent mechanisms. Ric-8 belongs to a highly conserved protein family that regulates heterotrimeric G-protein function, acting as a non-canonical guanine nucleotide exchange factors (GEF) over a subset of Gα subunits. In this review we discuss the roles of Ric-8 in the regulation of diverse cell functions, emphasizing the contribution of its multiple domain protein structure in these diverse functions.
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