The R-DoC initiative: science and practice

A research focus upon dimensions of observable behaviors and neurobiological indices, as outlined in the R-DoC initiative, is likely to enhance our understanding of psychopathology in a number of ways that are outlined in this article. Specific examples include a greater understanding of the mechanisms underlying comorbidity and complexity of symptom manifestation, individual differences in symptom expression, and developmental changes in symptom expression. Furthermore, the R-DoC approach may have treatment implications, including treatment efficacy, and identification of treatment moderators and treatment mediators.