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Updated: May 23, 2026
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Recurrent transitional cell carcinoma of the bladder: A mixed nested variant case report and literature review
Ettore De Berardinis1, Gian Maria Busetto, Riccardo Giovannone
1Sapienza Rome University, Policlinico Umberto I, Rome, Italy. ettore.deberardinis@uniroma1.it
Abstract:
Nested variant of urothelial cell carcinoma (NVUC) is a rare histological entity, with about 80 reported cases. It has a deceptively benign appearance with an aspect characterized by confluent small nest or urothelial's cell tubules. This tumour often resembles inverted papilloma, von Brunn's nests (VBNs), cystitis cystica, nephrogenic metaplasia and sometimes usual transitional cell cancer. It is very important to be able to distinguish between benign lesions and nested variant bladder cancer because, in spite of its bland morphology, there is evidence that it behaves aggressively.
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