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Updated: May 23, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
[Design, synthesis and activities of 4-(2-acetoxybenzoylamino) butyramide derivatives]
Wen-Hu Liu1, Shi-Bao Wang, Xian Yu
1Department of Pharmacology, School of Pharmacy, North Sichuan Medical College, Nanchong 637000, China. lwh790214@163.com
Abstract:
To explore new agents of gamma-aminobutyric acid (GABA) derivatives with more potent antiepileptic activity, a series of 4-(2-acetoxybenzoylamino) butyramide derivatives were designed and synthesized. All of the novel compounds (5a-51) were synthesized from GABA as starting material, and their structures were confirmed with IR, 1H NMR, EI-MS and elemental analysis. Preliminary pharmacological test in vitro showed that all target compounds displayed strong antiepileptic activities and were worth for further study. The structure-activity relationship of 4-(2-acetoxybenzoylamino) butyramide derivatives was also discussed preliminarily.
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