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Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Related Experiment Video

Updated: May 23, 2026

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
11:27

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Published on: November 18, 2013

Neural stem cells: brain building blocks and beyond.

Tobias Bergström1, Karin Forsberg-Nilsson

  • 1Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Upsala Journal of Medical Sciences
|April 20, 2012
PubMed
Summary
This summary is machine-generated.

Neural stem cells (NSCs) are crucial for brain development and function, persisting in the adult brain. Dysregulation of NSC number can lead to neurological disorders and brain tumors like glioma.

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Last Updated: May 23, 2026

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
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Enumeration of Neural Stem Cells Using Clonal Assays
10:32

Enumeration of Neural Stem Cells Using Clonal Assays

Published on: October 4, 2016

Area of Science:

  • Neuroscience
  • Stem Cell Biology

Background:

  • Neural stem cells (NSCs) are progenitor cells in the mammalian central nervous system, generating neurons and glia.
  • NSCs persist in the postnatal brain, contributing to lifelong neurogenesis in specific regions.
  • Proper regulation of NSC number is vital for preventing brain malformations, cognitive deficits, and tumor development.

Purpose of the Study:

  • To explore the role of neural stem cells in development and disease.
  • To investigate the potential of neural stem cells in treating neurological conditions.
  • To understand the link between neural stem cell pathways and glioma.

Main Methods:

  • Isolation and in vitro expansion of multipotent neural stem cells from embryonic and adult brains.
  • Derivation of neural stem cells from embryonic stem cells and induced pluripotent stem cells.
  • Molecular characterization of human gliomas and development of stem cell-like glioma models.

Main Results:

  • Signaling pathways crucial for NSC self-renewal, differentiation, survival, and migration are also implicated in glioma.
  • Novel stem cell-like glioma models offer insights into tumor heterogeneity and therapeutic strategies.
  • In vitro expansion of NSCs provides valuable models for studying stem cells in health and disease.

Conclusions:

  • Neural stem cells are fundamental to central nervous system development and adult neurogenesis.
  • Understanding NSC regulation is critical for addressing neurological diseases and brain tumors.
  • NSC research, including in vitro models, holds promise for developing new therapies for neurological disorders and gliomas.