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14-3-3 zeta as novel molecular target for cancer therapy
Ajay Matta1, K W Michael Siu, Ranju Ralhan
1York University, Department of Chemistry and Centre for Research in Mass Spectrometry , Toronto, Ontario , Canada.
Introduction:
14-3-3ζ acts as a central hub in signaling networks, which promotes cell proliferation, adhesion and survival and inhibits apoptosis in multiple cancers. Development of inhibitors or agents that interfere with 14-3-3ζ-dependent signaling networks are likely to serve as novel molecular agents for targeted cancer therapy.
Areas Covered:
The role of 14-3-3ζ in cancer and its potential as a novel molecular target for therapy. The involvement of 14-3-3ζ in chemoresistance in multiple cancers provides a rationale for developing novel molecular therapies targeting this protein for more effective cancer management. The keywords used to conduct the literature search for this paper were '14-3-3/14-3-3zeta and cancer', '14-3-3 structure', '14-3-3 inhibitors', '14-3-3 cancer prognosis', '14-3-3 and cancer therapy', 'role/ functions of 14-3-3'.
Expert Opinion:
14-3-3ζ is a central cellular hub protein regulating multiple signaling pathways involved in cancer development, progression and therapeutic resistance. Thus, 14-3-3ζ may serve as a novel molecular target for cancer therapy. New approaches including synthetic and/or natural inhibitors that interfere with 14-3-3ζ-client interactions need to be developed for effective cancer therapy.
Insights
14-3-3ζ protein is a key regulator in cancer cell growth and survival. Targeting this protein with new inhibitors offers a promising strategy for effective cancer therapy and overcoming chemoresistance.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- 14-3-3ζ is a crucial signaling hub protein involved in cancer cell proliferation, adhesion, survival, and apoptosis inhibition.
- Its dysregulation is implicated in the development and progression of multiple cancer types.
Purpose of the Study:
- To review the role of 14-3-3ζ in cancer.
- To explore its potential as a novel molecular target for cancer therapy.
- To highlight its involvement in chemoresistance.
Main Methods:
- Literature search using keywords: '14-3-3/14-3-3zeta and cancer', '14-3-3 structure', '14-3-3 inhibitors', '14-3-3 cancer prognosis', '14-3-3 and cancer therapy', 'role/ functions of 14-3-3'.
- Review of existing research on 14-3-3ζ function in cancer.
Main Results:
- 14-3-3ζ regulates critical signaling pathways essential for cancer development.
- The protein's role in chemoresistance suggests it as a target for enhancing treatment efficacy.
Conclusions:
- 14-3-3ζ is a central protein regulating cancer development, progression, and therapeutic resistance.
- Developing inhibitors that disrupt 14-3-3ζ interactions is a promising avenue for novel cancer therapies.
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