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Updated: May 23, 2026
08:31
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
Functionalized mesoporous silica particles for application in drug delivery system
1School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, 250012, P. R. China.
Mini Reviews in Medicinal Chemistry
|April 20, 2012
Summary
Functionalized mesoporous silica materials offer enhanced drug loading and controlled release for drug delivery systems. These advanced carriers show great potential for targeted and sustained therapeutic applications.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Ordered mesoporous silica materials are promising drug carriers due to their structure, surface area, and biocompatibility.
- These materials offer high drug loading capacity but lack inherent controlled release capabilities.
- Modification is necessary to achieve controlled drug release from silica-based mesoporous systems.
Purpose of the Study:
- To review recent research on functionalizing mesoporous materials for drug delivery.
- To highlight methods and components used for functionalization.
- To assess the potential of functionalized systems for targeted and controlled drug delivery.
Main Methods:
- Review of literature on functionalization techniques for mesoporous silica.
- Analysis of various components and methods for modifying mesoporous materials.
- Evaluation of functionalized materials for drug loading and release characteristics.
Main Results:
- Functionalization significantly enhances the control over drug release from mesoporous silica carriers.
- Various strategies exist for modifying mesoporous silica to achieve desired release profiles.
- Functionalized systems demonstrate potential for improved drug delivery efficacy.
Conclusions:
- Functionalized mesoporous silica-based systems are highly promising for advanced drug delivery.
- These materials offer tailored solutions for targeted and controlled drug release applications.
- Further research in functionalization will advance the field of drug delivery systems.
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