Related Experiment Video
Updated: May 23, 2026
Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration
Published on: June 9, 2023
Biological Activities and Corresponding Sar Analysis of Andrographolide and its Derivatives
Bin Zhou1, Dayong Zhang, Xiaoming Wu
1Center of Drug Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Abstract:
In recent years pharmaceutical chemists have synthesized large numbers of andrographolide derivatives, which bear important biological activities such as anti-inflammatory, antibacterial, antivirus, antitumor, antidiabetic, and antifeedant. Consequently, the corresponding SAR presents more and more pronounced. This paper aimed to review all the available literature on this field, which highlighted the significant achievements on the structural modification and SAR of andrographolide and its derivatives.
Related Concept Videos
01:28Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
01:16Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...