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Updated: May 23, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
Synthesis and evaluation of D-gluconamides as green mineral scales
Marcelo I P Reis1, Aline D Gonçalves, Fernando de C da Silva
1Universidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, Outeiro de S. João Batista, s/n°, Centro, 24020-150 Niterói, RJ, Brazil.
Abstract:
A series of 13 D-gluconamides were synthesized in moderate to good yields and evaluated as green scale inhibitors. The crystal structures of two compounds were determined by X-ray crystallography. The compounds 6c and 6d showed a reasonable inhibition of BaSO(4) precipitation from aqueous solution (47% and 51%, respectively) that indicated the potential for these derivatives of δ-gluconolactone.
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