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Heart failure survival score in patients with Chagas disease: correlation with functional variables
Luiz E Ritt1, Antonio Carlos Carvalho, Gilson S Feitosa
1Departamento de Cardiologia, Universidade Federal de São Paulo, São Paulo, Brazil.
Insights
The Heart Failure Survival Score effectively predicts outcomes in patients with Chagas disease-related heart failure. This score correlates well with key functional tests, offering valuable prognostic insights for this population.
Area of Science:
- Cardiology
- Tropical Medicine
- Public Health
Background:
- Chagas disease is a significant cause of heart failure in Latin America with a poorer prognosis than other etiologies.
- The Heart Failure Survival Score is established for heart failure prognosis but unstudied in Chagas cardiopathy.
Purpose of the Study:
- To evaluate the Heart Failure Survival Score's correlation with functional parameters in patients with Chagas cardiopathy.
Main Methods:
- Calculated the Heart Failure Survival Score in 55 patients with severe left ventricular systolic dysfunction due to Chagas disease.
- Assessed correlations between the score and cardiopulmonary exercise tests, quality of life, and 6-minute walking tests.
Main Results:
- The Heart Failure Survival Score showed strong correlations with peak oxygen uptake, anaerobic threshold, ventilation carbon dioxide efficiency, and 6-minute walking test distance.
- Significant correlations were also observed with left ventricle ejection fraction and left atrium diameter.
Conclusions:
- The Heart Failure Survival Score is a valuable tool for assessing prognosis in heart failure patients with Chagas disease.
- The score's strong correlation with functional test variables supports its utility in clinical practice for this population.
Introduction And Objectives:
Chagas disease is a prevalent cause of heart failure in Latin America, and its prognosis is worse than other etiologies. The Heart Failure Survival Score has been used to assess prognosis in patients with heart failure; however, this score has not yet been studied in patients with Chagas cardiopathy.
Methods:
The Heart Failure Survival Score was calculated in 55 patients with severe left ventricular systolic dysfunction due to Chagas disease. Correlations were assessed between the Heart Failure Survival Score and variables obtained from, cardiopulmonary exercise tests, quality-of-life measures, and 6-minute walking tests.
Results:
Patients were distributed among New York Heart Association classes II-IV; 89% were taking angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, 62% were taking beta-blockers, 86% were taking diuretics, and 74% were taking aldosterone receptor blockers. The mean Heart Failure Survival Score was 8.75 (0.80). The score correlated well with cardiopulmonary test variables such as peak oxygen uptake (0.662; P<.01), oxygen uptake at the anaerobic threshold (0.644; P<.01), ventilation carbon dioxide efficiency slope (-0.417; P<.01), oxygen pulse (0.375; P<.01), oxygen uptake efficiency slope (0.626; P<.01), 6-minute walking test (0.370; P<.01), left ventricle ejection fraction (0.650; P=.01), and left atrium diameter (-0.377; P<.01). There was also a borderline significant correlation between the Heart Failure Survival Score and quality of life (-0.283; P<.05).
Conclusions:
In heart failure patients with Chagas disease, the Heart Failure Survival Score correlated well with the main prognostic functional test variables.
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