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CASP8 -652 6N del polymorphism and cancer risk: a meta-analysis of 30 case-control studies in 50,112 subjects

Fan Zhang1, Yuan Yang, Cheng Guo

  • 1Department of Maternal and Child Health, School of Public Health and Health Management, Chongqing Medical University, Chongqing 400016, China.

Mutagenesis
|April 20, 2012
PubMed

Insights

The CASP8 -652 6N del polymorphism is linked to a reduced risk of cancer. This genetic variation shows a protective effect, particularly in Asian and Caucasian populations and for colorectal cancer.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Apoptosis, regulated by caspases, is crucial in preventing cancer development.
  • The CASP8 gene encodes caspase-8, vital for T lymphocyte apoptosis.
  • Previous studies on the CASP8 -652 6N del polymorphism and cancer risk yielded inconsistent results.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between the CASP8 -652 6N del polymorphism and cancer risk.
  • To synthesize findings from multiple studies to overcome individual study limitations.

Main Methods:

  • A meta-analysis combining data from 30 case-control studies.
  • Inclusion of 23,700 cancer cases and 26,412 controls.
  • Analysis of allele contrast, additive, dominant, and recessive genetic models.

Main Results:

  • The CASP8 -652 6N del polymorphism was associated with a decreased overall cancer risk across various genetic models.
  • Stratified analyses revealed a significantly reduced risk for Asians and Caucasians.
  • A reduced risk was also observed in the colorectal cancer group and an 'other cancers' group.

Conclusions:

  • The CASP8 -652 6N del polymorphism is associated with a reduced risk of cancer.
  • This protective effect is particularly notable in Asian and Caucasian populations and for individuals with colorectal cancer.
  • Further research is recommended to explore additional ethnic groups and cancer types for a comprehensive understanding.

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