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Updated: May 23, 2026

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
Published on: April 11, 2019
Asystole in ultrabrief pulse electroconvulsive therapy.
Jennifer M Coughlin1, Kyle Rodenbach, Pin-Hsuan Lee
1The Johns Hopkins University School of Medicine, Baltimore, MD, USA. jcoughl2@jhmi.edu
Ultrabrief (UB) pulse electroconvulsive therapy (ECT) did not prolong cardiac pause compared to brief pulse ECT. Cardiac pause length was sensitive to stimulus duration with brief pulses, but not pulse width with UB pulses.
Area of Science:
- Neurology
- Cardiology
- Psychiatry
Background:
- Ultrabrief (UB) pulse electroconvulsive therapy (ECT) is increasingly used due to a better cognitive side effect profile than brief pulse ECT.
- UB pulses delivered at maximal charge last 8 seconds.
- Electrical stimulation during ECT can cause parasympathetic surges and transient asystole.
Purpose of the Study:
- To compare cardiac pause length between 8-second UB pulses and 4-second brief pulses delivered at maximal charge.
- To investigate the effect of pulse width and duration on cardiac pause during ECT.
Main Methods:
- Retrospective study analyzing cardiac pause length in patients undergoing ECT.
- Data collected from The Johns Hopkins Hospital over a 1-year period.
- Focus on right unilateral ECT placement at maximal charge.
Main Results:
- Pulse width did not affect electrocardiac pause length for right unilateral ECT at maximal charge.
- Cardiac pause length was significantly influenced by stimulus duration (2 vs. 4 seconds) with brief pulses (P < 0.0001).
Conclusions:
- Right unilateral ECT at maximal charge is not affected by pulse width.
- Findings suggest pulse duration, not width, is a key factor in cardiac pause for brief pulse ECT, despite study limitations like small sample size and retrospective design.
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