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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Highly biocompatible, hollow coordination polymer nanoparticles as cisplatin carriers for efficient intracellular
Hong-Yuan Lian1, Ming Hu, Chia-Hung Liu
1Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
Chemical Communications (Cambridge, England)
|April 20, 2012
Abstract:
Highly biocompatible coordination polymer (Prussian Blue) nanoparticles (LC(50) > 1000 μg mL(-1)) with a hollow interior and a microporous framework (denoted as HPB) are utilized as an anticancer drug (i.e. cisplatin) capsule for chemotherapy of bladder cancer T24 cells.
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