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siRNA - Small Interfering RNAs

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...

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Related Experiment Video

Updated: May 23, 2026

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

Self-assembling peptide-based nanoparticles for siRNA delivery in primary cell lines

Sébastien Deshayes¹, Karidia Konate, Anna Rydström

¹Centre de Recherches de Biochimie Macromoléculaire, Department of Molecular Biophysics and Therapeutics, CNRS UMR-5237, UM1-UM2 University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France.

Small (Weinheim an Der Bergstrasse, Germany)

|April 20, 2012

Summary

No abstract available in PubMed .

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