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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Androgens, diabetes and prostate cancer
Mathis Grossmann1, Gary Wittert
1Department of Medicine Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.
Endocrine-Related Cancer
|April 20, 2012
Summary
Metabolic disorders like obesity and diabetes impact prostate cancer (PCa) risk and aggressiveness. Obesity may worsen PCa, while long-standing diabetes might offer protection, possibly due to hormonal changes.
Area of Science:
- Oncology
- Endocrinology
- Metabolic Research
Background:
- Metabolic disorders, including obesity and diabetes, are increasingly recognized as significant modulators of prostate cancer (PCa) risk and progression.
- Observational and experimental studies suggest complex interactions between metabolic health, sex hormones, and PCa development.
- Obesity is linked to increased PCa aggressiveness and poorer outcomes, while long-standing diabetes may paradoxically reduce PCa incidence.
Purpose of the Study:
- To review the epidemiological and mechanistic evidence on the interplay between metabolic conditions, sex steroids, and prostate cancer.
- To elucidate the dual role of metabolic disorders in PCa risk and aggressiveness.
- To discuss the metabolic consequences of androgen deprivation therapy in PCa management.
Main Methods:
- Review of existing epidemiological data on metabolic disorders and PCa.
- Analysis of experimental studies investigating mechanistic links.
- Examination of hormonal pathways, including insulin, IGF1, and androgens.
- Assessment of the metabolic impact of androgen deprivation therapy.
Main Results:
- Obesity and associated insulin excess correlate with increased PCa aggressiveness and adverse outcomes.
- Long-standing diabetes, potentially due to insulin depletion and reduced IGF1 signaling, may be protective against PCa development.
- Both obesity and diabetes are associated with altered androgen levels, complicating the understanding of their individual roles.
Conclusions:
- Metabolic factors and androgens interact through mechanisms like inflammation, adipokine signaling, fatty acid metabolism, and IGF signaling to influence prostate carcinogenesis.
- The complex relationship between metabolic status and androgens necessitates careful consideration in PCa risk assessment and treatment.
- Adverse metabolic effects of androgen deprivation therapy require evaluation for risk-benefit assessment in prostate cancer management.
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